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remains unexplained after thorough evaluation, it has been our practice to administer an anticonvulsant and to re-evaluate the situation in a matter of 6 to 12 months, with the goal of eventually discontinuing medication Usually, a second MRI and EEG are performed to exclude focal abnormalities that were not appreciated during the initial evaluation, but often these studies are again unrevealing This approach has been prompted by data such as those of Hauser and colleagues, who found that about one-third of patients with a single unprovoked seizure will have another seizure within 5 years; the risk is even greater if there is a history of seizures in a sibling, a complex febrile convulsion in childhood, or a spike-and-wave abnormality in the EEG Moreover, the risk of recurrence is greatest in the rst 24 months In patients with two or three unexplained seizures, three-quarters have further seizures in the subsequent 4 years

The use of antiepileptic drugs is the most important facet of treatment In approximately 70 percent of all patients with epilepsy, the seizures are controlled completely or almost completely by the use of antiepileptic drugs; in an additional 20 to 25 percent, the attacks are signi cantly reduced in number and severity The most commonly used drugs are listed in Table 16-5, along with their dosages, effective blood levels, and serum half-lives Because of the long half-lives of phenytoin, phenobarbital, and ethosuximide, these drugs need be taken only once daily, preferably at bedtime Valproate and carbamazepine have shorter half-lives, and their administration should be spaced during the day It is also useful to be familiar with the serum protein-binding characteristics of antiepileptic drugs and the interactions among these drugs, and between antiepileptic and other drugs Certain drugs are somewhat more effective in one type of seizure than in another, and it is necessary to use the proper drugs in optimum dosages for different circumstances Initially, only one drug should be used and the dosage increased until sustained therapeutic levels have been attained If seizures are not controlled by

The treatment of epilepsy of all types can be divided into four parts: the use of antiepileptic drugs, the surgical excision of epileptic foci and other surgical measures, the removal of causative and precipitating factors, and the regulation of physical and mental activity

Lamotrigine, oxcarbazepine Lamotrigine Valporate, lamotrigine, oxcarbazine Ethosuximide, lamotrigine Lamotrigine

volatility and time value decay while having a position farther away from the current market than the straddle Unlike the long strangle, you would not want to be utilizing in-the-money positions for the short strangle The trade needs to be entirely extrinsic value and be typically the farthest away from the current market so that you can achieve a reasonable premium Let s look at a model of the short strangle using MCD Options again (See Figure 720 above) If we consider selling ve of the June MCD 65 call options and ve of the June MCD 50-put options for a combined premium of 417 We take in a total premium of $2,085 We can calculate our breakeven by adding the combined premium to the call option strike price of 65, so the upside breakeven is now 6917 On the downside the breakeven is 4583, leaving us a range in which the trade has pro tability minus trading costs between these two points If we look at the model for this trade in Figure 723, we can see a similar pattern to the short straddle with the familiar at area between the two strike prices

is critical for making comparisons You will see that there are numerous situations where being able to display sales dollars and percentages of sales on the same chart is critical and more than likely a requirement If the value ranges of data series vary considerably or if mixed data types are used, you can plot one or more data series to a secondary axis (Y axis) For example, you can plot the number of houses sold on the left Y axis (primary axis) and the average price on the right Y axis (secondary axis) To do this, you will, of course, need the data in the appropriate format in your report and also have two data series To accomplish, first select the property Data Series Format and open the data series you want to edit (for example, Dataseries1) Then, depending on whether the horizontal axis or the vertical axis in your diagram is the value axis, select the value Secondary in the Horizontal Axis or Vertical Axis field

Valproate and lamotrigine or levetiracetam Valproate and ethosuximide Carbamazepine and valproate Vigabatrin and lamotrigine or tiagabine Topiramate and lamotrigine or levetiracetam

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Partial or generalized seizures Generalized absence Complex partial seizures Partial seizures Numerous types

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data label to the axis You can do this for all data series, a single data series, or a data point Finding the appropriate location to set up the labeling can be a bit tricky To add data labels to a single data series, select the property Series | Series 1 | Show Labels, whereby Series 1 stands for the series for which you want to add the label Enter the content to be displayed on the label into the Format field There are many possibilities that you can implement here using simple syntax The formal syntax for the data label is {free text}{indicator} {0} [,|] {0} {free text}, whereby the first position specifies if the value is absolute or a numeric percentage value or name of the field, the second position defines the number format, and the last position allows free text input for specifying the unit You can also enter a number format using zero and thousand separators or decimal points as required Remember the following: Country-specific settings can influence the number format that is displayed You can override the country-specific settings by using the separator $Sep Normally, two decimal places are used If you use country-specific settings, then you can have a comma rather than a decimal place for the format The same applies for the thousand separators for example, 100000 in US formatting versus 1000,00 in EUR formatting

Adapted by permission from Brodie MJ, Schachter SC Epilepsy, 2nd ed Oxford, England, Health Press, 2001