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forced to choose between increased effectiveness and higher cost. At the microeconomic level, sound economic evidence, such as cost-effectiveness studies, will be needed to make ef cient and rational use of scarce health care resources. From a societal perspective, we need to appreciate not only the drug costs but also the effects on total health care expenditure and societal well-being of using the newer agents. The value of a pharmaceutical intervention is re ected not only in clinical consequences but also in economic and humanistic outcomes (Kozma et al., 1993). To assess the value of medical innovations such as pharmacogenomics-based drugs, it is necessary to consider their impact on all three types of outcomes simultaneously.

due to a broken right foot. Finally, Jay is followed by a child psychiatrist for anxiety and depression for which he is currently prescribed sertraline (Zoloft). As a result, neuropsychological evaluation was undertaken in order to assess higher cortical functioning and make appropriate recommendations regarding school placement and the need for supportive therapies.

This is intended to help with accommodating multicast ows Now for a closer look at RSVP RSVP includes seven messages: PATH, PathTear, RESV, ResvTear, ResvConf, PathErr, ResvErr At a very high level, these messages perform the following functions:.

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US$16 billion. The company s top three international markets (the United Kingdom, Germany, and Japan) accounted for another US$20 billion in catalog sales. Furthermore, Lands End conducted nearly 20 percent of its U.S. business over the Internet in 2001, and more than 25 percent of those online buyers were new customers. On top of that, the online customer is more pro table to Lands End than its traditional catalog buyer. The company s planners clearly smell pro table new revenue in key markets outside the States.

agents. The exact mechanism by which these agents stop viral infections is still uncertain, but it is thought that incorporation in DNA or RNA may play a role. A series of now widely used antiviral drugs have come from a modi cation in which the ve-membered sugar is replaced by an open-chain equivalent. That portion of the molecule is depicted in the representatives in Figure 4 in admittedly tortured form to show the relation between the natural and open forms. The rst of these compounds acyclovir, came from a long-standing program at the Burroughs Wellcome Labs on modi ed nucleosides and nucleotides. This compound in essence opens the ring by omitting one carbon atom and the oxygen atom thereon. The actual synthesis of course involves a quite different route.7 The drug is active against a range of herpes viruses and is indicated for cold sores, shingles, and genital herpes. It is also useful for treating chicken pox as a result of its activity against the varicella virus. The later analog ganciclovir8 restores to the sugar surrogate one of the hydroxyl groups present in the natural nucleoside. Ganciclovir is indicated for treating cytomegalovirus retinitis. The fused two-ring purine fragment in each of the two preceding agents is hooked to the side chain via a carbon atom

Summary

(1.65)

Usage:

wider and the individual signal spectra are very closely spaced (less than one signal bandwidth). For such cases it is very difficult to determine the IM interference analytically, even though the SSPA nonlinearity can be characterized accurately. In order to provide a quantitative characterization of an SSPA in terms of IM distortion, the noise power ratio (NPR) is introduced. The NPR data of a nonlinear device essentially provides an estimate for the signal-to-noise ratio at the output terminal due to IM products caused by multiple signal interference. The NPR of an SSPA at a test channel band is defined as the ratio between (a) the mean output noise power measured at the test channel band if the input port of the SSPA is connected with a band pass Gaussian noise source and (b) the mean output noise power measured at the test channel band if the input Gaussian noise source excludes the portion of the noise power that pertains to the test channel band. The block diagram for NPR measurement is shown in Figure 13.13, consisting of a white noise generator, a BPF, a band-reject notch filter, and a power meter. The bandwidth of the BPF should be equal to the total bandwidth of the channels. In the first part of the measurement, the BPF is directly connected to the SSPA input and the noise power at the test channel band is recorded. In the second part, the input noise at the test channel band must be zero, which is enforced by passing the bandpass noise through the notch filter. In Figure 13.14 we present conceptual sketches of power meter displays for an NPR measurement. The input consists of seven channels (possibly with a guard

: overcurrent protection devices : directional protection devices : short-circuit current fed by source 1 : short-circuit current fed by source 2

Usage:

The equivalent diagram is shown in Figure 10-25.

is also frequently used in the Astrakan method. The international standard language IDEF0 is also built upon these theories and principles.

4. In our management application console, the drawing functionality could be moved to the root interface.

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