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This is due to a sudden reduction in cardiac output, usually because of an arrhythmia, predominantly a bradyarrhythmia Normally, a pulse as low as 35 to 40 beats per minute or as high as 150 beats per minute is well tolerated, especially if the patient is recumbent Changes in pulse rate beyond these extremes impair cardiac output and may lead to syncope Upright posture, anemia, and coronary, myocardial, and valvular disease all render the individual more susceptible to these alterations Detailed discussions of the various valvular and myocardial abnormalities and arrhythmias that may compromise cardiac output and lead to syncope are to be found in the articles by Lipsitz, by Manolis, and by Kapoor and colleagues, listed in the References Syncope of cardiac origin occurs most frequently in patients with complete atrioventricular block and a pulse rate of 40 or less per minute (Adams-Stokes-Morgagni syndrome) The block may be persistent or intermittent; it is often preceded by fascicular or second-degree heart block Ventricular arrest of 4 to 8 s, if the patient is upright, is enough to cause syncope; if the patient is supine, the asystole must last 12 to 15 s After asystole of 12 s, according to Engel, the patient turns pale and becomes momentarily weak or may lose consciousness without warning; this may occur regardless of the position of the body If the duration of cerebral ischemia exceeds 15 to 20 s, there are a few clonic jerks With still longer asystole, the clonic jerks merge with tonic spasms and stertorous respirations and the ashen-gray pallor gives way to cyanosis, incontinence, xed pupils, and bilateral Babinski signs As heart action resumes, the face and neck become ushed The report of this sequence of signs by a dependable observer helps to distinguish syncope from epilepsy In cases of even more prolonged asystole (4 to 5 min), there may be cerebral injury, caused by a combination of hypoxia and ischemia Coma may persist or may be replaced by confusion and other neurologic signs Focal ischemic changes, often irreversible, may then be traced to the elds of occluded atherosclerotic cerebral arteries or the border zones between the areas of supply of major arteries Cardiac faints of the Stokes-Adams type may recur several times a day The heart block is usually intermittent at rst, and between attacks the electrocardiogram (ECG) may show only evidence of myocardial disease A continuous ECG using a Holter monitor or telemetry is then needed to demonstrate the arrhythmia (see further on) Less easily recognized are faintness and syncope due to dysfunction of the sinus node, manifest by marked sinus bradycardia, sinoatrial block, or sinus arrest ( sick sinus syndrome ) The nodal block results in prolonged atrial asystole (03 s) Supraventricular.

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tachycardia or atrial brillation may occur, alternating with sinus bradycardia (bradycardia-tachycardia syndrome) Tachyarrhythmias alone are less likely to produce syncope Certainly intermittent ventricular brillation can cause fainting, and supraventricular tachycardias with rapid ventricular responses (usually over 180 beats per minute) cause syncope when sustained, predominantly in patients who are upright at the time The long QT syndrome is a rare familial condition in which syncope and ventricular arrhythmias are prone to occur Mutations in at least six different genes encoding cardiac sodium and potassium channels cause this syndrome Another inherited syndrome with right bundle branch block and ST-segment elevation in the right precordial leads is known to cause syncope and even sudden death (Brugada syndrome) Some patients with mitral valve prolapse seem disposed to syncope and presyncope and an inordinate number are also said to have panic attacks Aortic stenosis or subaortic stenosis from cardiomyopathy often sets the stage for exertional syncope, because cardiac output cannot keep pace with the demands of exercise Primary pulmonary hypertension and obstruction of right ventricular out ow (pulmonic valvular or infundibular stenosis) or intracardiac tumors may also be associated with exertional syncope Syncope may also be a manifestation of pulmonary embolism Vagal overactivity may be a factor contributing to the syncope in these conditions as well as in the syncope that may accompany pulmonary embolus and acute aortic out ow obstruction Tetralogy of Fallot is the congenital cardiac malformation that most often leads to syncope Other cardiac causes are listed in the classi cation given at the opening of this chapter

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An associated problem, with which we have had numerous unsatisfactory encounters, is posed by the patient who falls suddenly forward without apparent cause, awakens with headache, and is found to have bifrontal hematomas and subarachnoid blood on CT These cases highlight the dif culty of distinguishing a primary aneurysmal subarachnoid hemorrhage from an accidental fall or syncope with secondary frontal brain contusions; in almost every case, we have felt obliged to perform cerebral angiography to exclude an anterior communicating artery aneurysm, but we have rarely found one

Hysterical fainting is rather frequent and usually occurs under dramatic circumstances (Chap 56) The evident lack of change in pulse, blood pressure, or color of the skin or any outward display of anxiety distinguishes it from the vasodepressor faint Irregular jerking movements and generalized spasms without loss of consciousness or change in the EEG are typical features The diagnosis is based on these negative ndings in a person who exhibits the general personality and behavioral characteristics of hysteria Several interesting instances of mass faintness and syncope of hysterical type have been described for example, in school marching bands (RJ Levine)

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Finally, after careful evaluation of patients with syncope and the exclusion of the many forms of the condition described above, there remains a signi cant proportion (one-third to one-half, according to Kapoor and 40 percent in the earlier noted Framingham Heart Study) in which a cause for the syncope cannot be ascertained The question of whether a single positive tilt-table test signi es that a prior episode of syncope was neurocardiogenic is not resolved; this obviously has a bearing on the proportion of cases that remain without a diagnosis If the episodes are repetitive and erratically spaced, a cardiac arrhythmia or intraventricular conduction defect should be sought by use of special monitoring devices and conduction studies

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