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The protection that patients are afforded from adverse drug effects does not begin with pharmacist monitoring. In fact, pharmacists are the nal professional risk evaluators in a long chain of careful decisions about risk that precede dispensing of a medication to a patient. The highly paternalistic drug regulatory process constructs formidable barriers to prevent patients from making foolish choices in the use of medications. A molecule may be developed and otherwise available for use as a pharmaceutical product, but unless that product has been scienti cally shown to be safe and effective for the population of users, and unless a highly trained medical professional has determined that the drug will be appropriate for a speci c individual within the population, the opportunity to use the molecule will be denied. New drugs must be proven safe and effective before being placed into interstate commerce, and most newly approved drugs are limited to prescription-only status. The cautious approach to drug approval, as overseen by the federal Food and Drug Administration (FDA), has been described in detail elsewhere (Findlay, 1999). The risks and bene ts of a new drug submitted for FDA approval are rigorously studied through randomized, controlled clinical trials. Despite the enormous effort put forth to study new drugs, and the huge nancial investment required to support clinical trials, many questions are often left unanswered by the relatively small-scale preapproval studies that may fail to detect, or fully describe, low-incidence adverse effects. These adverse effects may become evident within the months or years immediately

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which is a diagonal matrix of order M M. The off-diagonal terms are zero because an interface does not cause any coupling between the Floquet modes assuming that TEz and TMz types of modes are used, where the z-axis is normal to the interface. To obtain [S21 ], we need to find the transmitted voltage with respect to the incident voltage when the output port is match terminated. Form the continuity condition we know that the total voltage before the interface and after the interface must remain unchanged. The total voltage before the interface for the ith mode is given by v i = a+ i + a i = 1 + 1 1

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y latest client, Frank, was from New Jersey, an Italian-American who was in waste management. And just when it was all starting to sound like something from an episode of The Sopranos, someone at the company quietly told me that they had hired a new chief of operations, an ivy leaguer whose father used to be one of New York s leading labor gures one with reputed mob ties. So it was true everyone was coming to China. Waste Corp was a trash hauler in the traditional sense. It had routes in residential parts of New Jersey as well as commercial accounts in New York City. In addition to picking up garbage, the company also collected recyclable paper. The company had set up a venture with a partner in Jiangmen, a town just a couple hours south of Guangzhou. Frank had even put $1 million of his own money into the project, but after operating for a year, the business still remained a mystery to him. But everything at the venture was ne, he insisted. Before the joint venture was conceived, Waste Corp sold its recyclable papers to brokers on the East Coast, who then sold the paper to Hong Kong agents, who in turn sold it to companies inside China. The idea behind the venture was to sell the paper to the paper mills directly. The partner, Winston, was running the 158

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Process Owner and Program Manager positions that make up the Level 2 processes of the APQC Process Classi cation FrameworkSM in Exhibit 6.12. In the case of our product development example, two distinct Level 2 processes, 2.1 Manage product and service portfolio and 2.2 Develop products and services, roll up to the category 2.0 Develop and Manage Products and Services. Process owners are the operating personnel who are responsible for the day-to-day activities of the Level 2 processes, typically at the general manager (GM) level. They serve mainly as advisors but they are also there to remove roadblocks that may hinder a team. If there are several GMs with responsibility in a category, pick the ones who have the most responsibility in the Level 2 processes. The next positions to ll are those of the Program Managers. They are the team leaders for each of the Level 2 processes and report to the CI Champion of the category. They should come from the organization they work in but not necessarily from the Level 2 process they will lead. Exhibit 6.13 depicts what a typical BPI structure for our product development example looks like.

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