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; The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2 J Virol 1992, 66, 1943 1950 44 Carroll, K; Elroy-Stein, O; Moss, B; Jagus, R Recombinant vaccinia virus K3L gene product prevents activation of double-stranded RNA-dependent initiation factor 2 alphaspeci c protein kinase J Biol Chem 1993, 268, 12837 12842 45 Barquet, N; Domingo, P Smallpox: the triumph over the most terrible of the ministers of death Ann Intern Med 1997, 127, 635 642 46 Tizard, I Grease, anthraxgate, and kennel cough: a revisionist history of early veterinary vaccines Adv Vet Med 1999, 41, 7 24 47 Yuen, L; Moss, B Oligonucleotide sequence signaling transcriptional termination of vaccinia virus early genes Proc Natl Acad Sci USA 1987, 84, 6417 6421..

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The C# and VB.NET PDF Library. C Sharp ASP .NET PDF Generator / Writer. A DLL in C# asp.net to generate and Edit PDF documents in .Net framework and .

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Table 17.2 DNA Recognition Sequences Utilized by Steroid, Estrogen, and Thyroid Receptor Family Members Receptor Family Steroid Estrogen Thyroid Recognition Sequence AGAACA . . . TGTTCT AGGTCA . . . TGACCT AGGTCA . . . AGGTCA

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6 A Erramilli, O Narayan, and W Willinger Experimental queueing analysis with longrange dependent packet traf c IEEE=ACM Trans Networking, 4(2):209, 1996 7 A Feldmann, A C Gilbert, and W Willinger Data networks as cascades: investigating the multifractal nature of internet WAN traf c In ACM SIGCOMM '98, p 42, 1998 8 M W Garret and W Willinger Analysis, modeling and generation of self-similar VBR video traf c In Proc ACM SIGCOMM '94, p 269, 1994 9 M Grossglauser and J-C Bolot On the relevance of long-range dependence in network traf c In Proc ACM SIGCOMM '96, p 15, 1996 10 D P Heyman and T V Lakshman What are the implications of long-range dependence for VBR-video traf c engineering IEEE=ACM Trans Networking, 4(3):301, 1996 11 W E Leland, M S Taqqu, W Willinger, and D V Wilson On the self-similar nature of Ethernet traf c (extended version).

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Figure 17.4 Intracellular steroid receptor activation by hormone ligands. (a) Steroid hormones diffuse across the cell membrane into the cell. (b) Steroid hormone receptors in the basal state bound to accessory proteins. (c) Steroid hormones bind to receptors and accessory proteins are dissociated from the receptors. (d) Hormone : receptor complexes dimerize. (e) Dimer complexes enter the nucleus and initiate transcription of responsive genes.

48 Mahr, A; Roberts, B E Arrangement of late RNAs transcribed from a 71 kilobase Eco RI vaccinia virus DNA fragment J Virol 1984, 49, 510 520 49 Langland, J O; Jacobs, B L Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L Virology 2004, 324, 419 429 50 Beattie, E; Paoletti, E; Tartaglia, J Distinct patterns of IFN sensitivity observed in cells infected with vaccinia K3L- and E3L- mutant viruses Virology 1995, 210, 254 263 51 Langland, J O; Jacobs, B L The role of the PKR-inhibitory genes, E3L and K3L, in determining vaccinia virus host range Virology 2002, 299, 133 141 52 Beattie, E; Tartaglia, J; Paoletti, E Vaccinia virus encoded eIF-2a homolog abrogates the antiviral effects of interferon Virology 1991, 183, 419 422 53 Koromilas, A E; Roy, S; Barber, G.

IEEE=ACM Trans Networking, 2((1):1, 1994 12 G-L Li, J-H Cui, F-M Li, and B Li Transient loss performance of a class of nite buffer queueing systems In ACM=IFIP SIGMETRICS=PERFORMANCE '98, p 111, 1998 13 G-L Li and V O K Li Transient call blocking probabilities: computation and applications Submitted for publication 14 G-L Li and V O K Li Explicit steady-state solutions of general queueing models with a single server Technique Report, Department of Electrical and Electronic Engineering, The University of Hong Kong, 1999 15 N Likhanov, B Tsybakov, and N D Georganas Analysis of an ATM buffer with selfsimilar (``fractal'') input traf c In Proc IEEE INFOCOM, p 985, 1995 16 I Norros On the use of fractional Brownian motion in the theory of connectionless networks IEEE J Select Areas Commun, 13(6):953, 1995 17 B K Ryu and A Elwalid.

In contrast to the steroid receptor family, members of the thyroid receptor family typically do not associate with accessory proteins and are not localized to the extranucleus matrix. Rather, these receptors exist in the basal state associated with chromatin in the cell nucleus. When bound by hormone ligand, thyroid receptor family members dissociate from the chromatin and typically form heterodimeric combinations with the retinoid-X receptor (RXR). RXR also is capable of homodimerization in association with its ligand 9-cis retinoic acid. Thus high 9-cis retinoic acid levels apparently promote homodimerization, and low levels are permissive of heterodimerization of RXR with activation by the partner ligand. The estrogen receptor shares structural and functional attributes of both nuclear receptor families. For example, the estrogen receptor resides in the cell nucleus, but it associates with accessory proteins rather than chromatin. The estrogen receptor shares a high degree of sequence homology with the thyroid receptor family members but does not heterodimerize with RXR. Rather, active estrogen receptor exists as a homodimer. The observation that the estrogen receptor shares attributes of both nuclear receptor families supports nucleotide sequence evidence that the estrogen receptor is an ancestral precursor to both receptor families.

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