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65 Romano, P R; Zhang, F; Tan, S; Garcia-Barrio, M T; Katze, M G; Dever, T E; Hinnebusch, A G Inhibition of double-stranded RNA-dependent protein kinase PKR by vaccinia virus E3: role of complex formation and the E3 N-terminal domain Mol Cell Biol 1998, 18, 7304 7316 66 Shors, T; Kibler, K V; Perkins, K B; Seidler-Wulff R; Banaszak, M P; Jacobs, B L Complementation of vaccinia virus deleted of the E3L gene by mutants of E3L Virology 1997, 239, 269 276 67 Shors, S T; Beattie, E; Paoletti, E; Tartaglia, J; Jacobs, B L Role of the vaccinia virus E3L and K3L gene products in rescue of VSV and EMCV from the effects of IFN-a J Interferon and Cytokine Res 1998, 18, 721 729 68 Yuwen, H; Cox, J H; Yewdell, J.

Estrogen Receptor. Among the steroid hormone receptors, the estrogen receptor appears most susceptible to the agonistic action of xenobiotics. Estrogen receptor agonists are quite diverse in molecular structure (Figure 17.6). Several steric considerations, associated with the steroid structure, in conjunction with electrostatic (charge) properties of the outer surface of the molecule seem to dictate whether a xenobiotic can t into the binding-pocket of the receptor and function as a receptor agonist. It is not clear why the estrogen receptor would be more susceptible to the agonistic action of xenobiotics as compared to other steroid hormone receptors. High ligand speci city may be an evolutionary trait of most modern receptors that is not associated with this presumed ancestral precursor to other nuclear receptor superfamily members. The estrogen receptor is often referred to as a promiscuous receptor because of this susceptibility to agonistic interactions with xenobiotics. Some drugs are rather potent estrogens (i.e., DES); however, environmental chemicals with estrogenic activity are typically weak agonists with activity several orders-ofmagnitude less than that of 17 -estradiol (Table 17.3). Because of this weak activity, xenoestrogens are typically not associated with endocrine toxicity to adult females owing to the large amount of 17 -estradiol in these individuals. However, adult males, immature individuals, and embryos all have been shown to exhibit endocrine toxicity resulting from xeno-estrogen exposure. For example, in utero exposure of male or female rodents and humans to DES causes proliferation of epithelial cells associated with the reproductive system resulting in abnormalities of this system. Gynecomastia is a common side effect of estrogenic drugs such as DES and fosfestrol when administered to adult males. The physiological consequences of xeno-estrogenic activity is typically characteristic of feminization, that is, the acquisition of female characteristics.

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dependence of mean queue length on self-similarity is consistent with previous works [2, 15, 16] showing that queue length distribution decays more slowly for long-range dependent (LRD) sources than for short-range dependent (SRD) sources. The aforementioned traf c-shaping effect of ow-controlled, reliable transport transforming a large le transfer into an on-average ``thin'' packet train (stretching-in-time effect) suggests, in part, why the on=off model has been so successful despite its limitations a principal effect of interaction among traf c sources in an internetworked environment lies in the generation of long packet trains wherein the correlation structure inherent in heavy-tailed le size distributions is suf ciently preserved. The rest of the chapter is organized as follows. In the next two sections, we discuss related work, the network model, and the simulation setup. This is followed by the main section, which explores the effect of le size distribution on traf c selfsimilarity, including the role of the protocol stack, heavy-tailed versus non-heavytailed interarrival time distribution, resource variations, and traf c mixing. We conclude with a discussion of the effect of traf c self-similarity from a performance evaluation perspective, showing its quantitative and qualitative effects with respect to performance measures when both the degree of self-similarity and network resources are varied.

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W; Bennink, J R; Moss, B Nuclear localization of a double-stranded RNA-binding protein encoded by the vaccinia virus E3L gene Virology 1993, 195, 732 744 69 DeGarcia, D J; Sullivan, J M; Neumar, R W; Alousi, S S; Hikade, K R; Pittman, J E; White, B C; Rafols, J A; Krause, G S Effect of brain ischemia and reperfusion on the localization of phosphorylated eukaryotic initiation factor 2a J Cerebral Blood Flow Metab 1997, 17, 1291 1302 70 Goldstein, E N; Owen, C R; White, B C; Rafols, J A Ultrastructural localization of phosphorylated eIF2a [eIF2a(P)] in rat dorsal hippocampus during reperfusion Acta Neuropathol 1999, 98, 493 505 71 Jeffrey, I W; Kadereit, S; Meurs, E F; Metzger, T; Bachmann, M; Schwemmle, M; Hovanessian, A G; Clemens, M J.

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