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Adapted by permission from Brodie MJ, Schachter SC Epilepsy, 2nd ed Oxford, England, Health Press, 2001

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the rst drug, a different drug should be tried, but frequent shifting of drugs is not advisable; each should be given an adequate trial before another is substituted A general approach to the choice of drug in certain common forms of epilepsy is given in Tables 16-6 for adults and 16-7 for children, but it must be noted that there are a number of drugs that may be appropriate in each circumstance A guide to various combinations of drugs that are helpful in refractory cases is given in Table 16-8 In changing medication, the dosage of the new drug should be increased gradually to an optimum level while the dosage of the old drug is gradually decreased; the sudden withdrawal of a drug may lead to an increase in seizure frequency or status epilepticus, even though a new drug has been substituted If seizures are still not controlled, a second drug can then be added Seldom if ever are more than two drugs necessary; the physician should make an effort to succeed with one drug and with no more than two given in adequate dosage Once an anticonvulsant or a combination of anticonvulsants is found to be effective, their use in most cases should be maintained for a period of years, or inde nitely if circumstances justify their long-term use Table 16-7 Choices of antiepileptic drugs in childhood seizure disorders

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Valproate, carbamazepine Valproate Valproate Carbamazepine, phenytoin Vigabatrin, corticosteroids Valproate

Finally, the free text enables you to type in some additional information to be displayed Remember to put the free text within for the display to work correctly Some examples of free text follow: "$Abs$Sep20,00" EUR" gives the label 12345689 EUR for a value of 1,23456 EUR "The percentage share is "$Percent0" %" gives the label The percentage share is 25 %

Lamotrigine, oxcarbazine Lamotrigine Lamotrigine, ethosuximide Valproate, gabapentin, oxcarbazine Valproate

SOURCE:

Adapted by permission from Brodie MJ, Schachter SC Epilepsy, 2nd ed Oxford, England, Health Press, 2001

$ 3,200 1,600 0 1,600 3,200 4,800 6,400 8,000 9,600 3550 3650 4250 4850 5450 6050 6650 7250 7850 8450

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The therapeutic dose for any given patient must be determined, to some extent, by trial and error and by measurement of serum levels, as described below Not uncommonly a drug is discarded as being ineffective, when a slight increase in dosage would have led to suppression of the attacks It is, however, also an error to administer a drug to the point where the patient is so dull and stupe ed that the toxic effects are more incapacitating than the seizures It is highly doubtful that prolonged administration of anticonvulsant medication is a factor in the development of the mental deterioration that occurs in a small percentage of patients with convulsive seizures In fact, improvement in mentation more often occurs following control of the seizures by the proper dosage of appropriate antiepileptic drugs The management of seizures with drugs is greatly facilitated by having patients chart their daily medication and the number, time, and circumstances of seizures Some patients nd it helpful to use a dispenser that is lled on Sunday, for example, with suf cient medication to last the week This indicates to the patient whether a dose had been missed and whether the supply of medications is running low The proper use of anticonvulsant drugs is considerably enhanced by the measurement of their serum levels The concentrations of almost all the commonly used drugs can be measured on a single specimen by immunoassay or by the older gas-liquid chromatography method These measurements are helpful in regulating dosage, detecting irregular drug intake, identifying the toxic agent in patients taking more than one drug, and assuring patient compliance Blood for serum levels is ideally drawn in the morning before breakfast and the rst ingestion of anticonvulsants ( trough levels ), a practice that introduces consistency in the measurement of drug concentrations The effective serum levels for each of the commonly used anticonvulsant drugs are indicated in Table 16-5 The upper and lower levels of the therapeutic range are not to be regarded as immutable limits within which the serum values must t In some patients, seizures are controlled at serum levels below the therapeutic range; in others, the seizures continue despite serum values within this range In the latter patients, seizures are sometimes controlled by raising levels above the therapeutic range but not to the point of producing clinical toxicity In general, higher serum concentrations of drugs are necessary for the control of simple or complex partial seizures than for the control of tonic-clonic seizures alone It is to be noted that the blood level is not a precise measure of the amount of drug entering the brain, because in the case of the most widely used anticonvulsants the larger proportion of.

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